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Conserved Hydrogen Bonds and Water Molecules in MDR HIV-1 Protease Substrate Complexes
The success of highly active antiretroviral therapy (HAART) in anti-HIV therapy is severely compromised by the rapidly developing drug resistance. HIV-1 protease inhibitors, part of HAART, are losing their potency and efficacy in inhibiting the target. Multi-drug resistant (MDR) 769 HIV-1 protease (...
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| Publicado no: | Biochem Biophys Res Commun |
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| Main Authors: | , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2012
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4520401/ https://ncbi.nlm.nih.gov/pubmed/23261453 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bbrc.2012.12.045 |
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