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Conserved Hydrogen Bonds and Water Molecules in MDR HIV-1 Protease Substrate Complexes

The success of highly active antiretroviral therapy (HAART) in anti-HIV therapy is severely compromised by the rapidly developing drug resistance. HIV-1 protease inhibitors, part of HAART, are losing their potency and efficacy in inhibiting the target. Multi-drug resistant (MDR) 769 HIV-1 protease (...

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Detalles Bibliográficos
Publicado en:Biochem Biophys Res Commun
Main Authors: Liu, Zhigang, Wang, Yong, Yedidi, Ravikiran S., Dewdney, Tamaria G., Reiter, Samuel J., Brunzelle, Joseph S., Kovari, Iulia A., Kovari, Ladislau C.
Formato: Artigo
Idioma:Inglês
Publicado: 2012
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Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC4520401/
https://ncbi.nlm.nih.gov/pubmed/23261453
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bbrc.2012.12.045
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