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Blockade of non-opioid excitatory effects of spinal dynorphin A at bradykinin receptors
Dynorphin A (Dyn A) is an endogenous opioid ligand that possesses neuroinhibitory (antinociceptive) effects via μ, δ, and κ opioid receptors. However, under chronic pain conditions, up-regulated spinal Dyn A can also interact with bradykinin receptors (BRs) to promote hyperalgesia through a neuroexc...
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| Опубликовано в: : | Receptors Clin Investig |
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| Главные авторы: | , , , , , , , , |
| Формат: | Artigo |
| Язык: | Inglês |
| Опубликовано: |
2015
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| Предметы: | |
| Online-ссылка: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4515361/ https://ncbi.nlm.nih.gov/pubmed/26221618 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.14800/rci.517 |
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