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The novel β2-selective proteasome inhibitor LU-102 decreases phosphorylation of I kappa B and induces highly synergistic cytotoxicity in combination with ibrutinib in multiple myeloma cells

PURPOSE: Proteasome-inhibiting drugs (PI) are gaining importance in hematologic oncology. The proteasome carries three proteolytically active subunits (β1, β2, β5). All established PI (bortezomib and carfilzomib), as well as experimental drugs in the field (dalanzomib, oprozomib, and ixazomib), by d...

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發表在:Cancer Chemother Pharmacol
Main Authors: Kraus, Johannes, Kraus, Marianne, Liu, Nora, Besse, Lenka, Bader, Jürgen, Geurink, Paul P., de Bruin, Gerjan, Kisselev, Alexei F., Overkleeft, Herman, Driessen, Christoph
格式: Artigo
語言:Inglês
出版: Springer Berlin Heidelberg 2015
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在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC4515249/
https://ncbi.nlm.nih.gov/pubmed/26099967
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00280-015-2801-0
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