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ALDH2 Deficiency Promotes Ethanol-Induced Gut Barrier Dysfunction and Fatty Liver in Mice

BACKGROUND: Acetaldehyde, the toxic ethanol metabolite, disrupts intestinal epithelial barrier function. Aldehyde dehydrogenase (ALDH) detoxifies acetaldehyde into acetate. Sub populations of Asians and Native Americans show polymorphism with loss of function mutations in ALDH2. We evaluated the eff...

詳細記述

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書誌詳細
出版年:Alcohol Clin Exp Res
主要な著者: Chaudhry, Kamljit K., Samak, Geetha, Shukla, Pradeep K., Mir, Hina, Gangwar, Ruchika, Manda, Bhargavi, Isse, Toyohi, Kawamoto, Toshihiro, Salaspuro, Mikko, Kaihovaara, Pertti, Dietrich, Paula, Dragatsis, Ioannis, Nagy, Laura E., Rao, RadhaKrishna
フォーマット: Artigo
言語:Inglês
出版事項: 2015
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC4515212/
https://ncbi.nlm.nih.gov/pubmed/26173414
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/acer.12777
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