Occludin Deficiency Promotes Ethanol-Induced Disruption of Colonic Epithelial Junctions, Gut Barrier Dysfunction and Liver Damage in Mice

BACKGROUND: Disruption of epithelial tight junctions (TJ), gut barrier dysfunction and endotoxemia play crucial role in the pathogenesis of alcoholic tissue injury. Occludin, a transmembrane protein of TJ, is depleted in colon by alcohol. However, it is unknown whether occludin depletion influences...

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Pubblicato in:Biochim Biophys Acta
Autori principali: Mir, Hina, Meena, Avtar S., Chaudhry, Kamaljit K., Shukla, Pradeep K., Gangwar, Ruchika, Manda, Bhargavi, Padala, Mythili K., Shen, Le, Turner, Jerrold R., Dietrich, Paula, Dragatsis, Ioannis, Rao, RadhaKrishna
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2015
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4776745/
https://ncbi.nlm.nih.gov/pubmed/26721332
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bbagen.2015.12.013
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