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Occludin Deficiency Promotes Ethanol-Induced Disruption of Colonic Epithelial Junctions, Gut Barrier Dysfunction and Liver Damage in Mice
BACKGROUND: Disruption of epithelial tight junctions (TJ), gut barrier dysfunction and endotoxemia play crucial role in the pathogenesis of alcoholic tissue injury. Occludin, a transmembrane protein of TJ, is depleted in colon by alcohol. However, it is unknown whether occludin depletion influences...
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| Vydáno v: | Biochim Biophys Acta |
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| Hlavní autoři: | , , , , , , , , , , , |
| Médium: | Artigo |
| Jazyk: | Inglês |
| Vydáno: |
2015
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| Témata: | |
| On-line přístup: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4776745/ https://ncbi.nlm.nih.gov/pubmed/26721332 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bbagen.2015.12.013 |
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