ALDH2 Deficiency Promotes Ethanol-Induced Gut Barrier Dysfunction and Fatty Liver in Mice

BACKGROUND: Acetaldehyde, the toxic ethanol metabolite, disrupts intestinal epithelial barrier function. Aldehyde dehydrogenase (ALDH) detoxifies acetaldehyde into acetate. Sub populations of Asians and Native Americans show polymorphism with loss of function mutations in ALDH2. We evaluated the eff...

Descripción completa

Guardado en:
Detalles Bibliográficos
Publicado en:Alcohol Clin Exp Res
Autores principales: Chaudhry, Kamljit K., Samak, Geetha, Shukla, Pradeep K., Mir, Hina, Gangwar, Ruchika, Manda, Bhargavi, Isse, Toyohi, Kawamoto, Toshihiro, Salaspuro, Mikko, Kaihovaara, Pertti, Dietrich, Paula, Dragatsis, Ioannis, Nagy, Laura E., Rao, RadhaKrishna
Formato: Artigo
Lenguaje:Inglês
Publicado: 2015
Materias:
Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC4515212/
https://ncbi.nlm.nih.gov/pubmed/26173414
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/acer.12777
Etiquetas: Agregar Etiqueta
Sin Etiquetas, Sea el primero en etiquetar este registro!

Ejemplares similares