ALDH2 Deficiency Promotes Ethanol-Induced Gut Barrier Dysfunction and Fatty Liver in Mice

BACKGROUND: Acetaldehyde, the toxic ethanol metabolite, disrupts intestinal epithelial barrier function. Aldehyde dehydrogenase (ALDH) detoxifies acetaldehyde into acetate. Sub populations of Asians and Native Americans show polymorphism with loss of function mutations in ALDH2. We evaluated the eff...

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Udgivet i:Alcohol Clin Exp Res
Main Authors: Chaudhry, Kamljit K., Samak, Geetha, Shukla, Pradeep K., Mir, Hina, Gangwar, Ruchika, Manda, Bhargavi, Isse, Toyohi, Kawamoto, Toshihiro, Salaspuro, Mikko, Kaihovaara, Pertti, Dietrich, Paula, Dragatsis, Ioannis, Nagy, Laura E., Rao, RadhaKrishna
Format: Artigo
Sprog:Inglês
Udgivet: 2015
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4515212/
https://ncbi.nlm.nih.gov/pubmed/26173414
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/acer.12777
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