Network analysis of immunotherapy-induced regressing tumours identifies novel synergistic drug combinations

Cancer immunotherapy has shown impressive results, but most patients do not respond. We hypothesized that the effector response in the tumour could be visualized as a complex network of interacting gene products and that by mapping this network we could predict effective pharmacological intervention...

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Bibliographic Details
Published in:Sci Rep
Main Authors: Lesterhuis, W. Joost, Rinaldi, Catherine, Jones, Anya, Rozali, Esdy N., Dick, Ian M., Khong, Andrea, Boon, Louis, Robinson, Bruce W., Nowak, Anna K., Bosco, Anthony, Lake, Richard A.
Format: Artigo
Language:Inglês
Published: Nature Publishing Group 2015
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4508665/
https://ncbi.nlm.nih.gov/pubmed/26193793
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep12298
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