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Network analysis of immunotherapy-induced regressing tumours identifies novel synergistic drug combinations

Cancer immunotherapy has shown impressive results, but most patients do not respond. We hypothesized that the effector response in the tumour could be visualized as a complex network of interacting gene products and that by mapping this network we could predict effective pharmacological intervention...

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Detalhes bibliográficos
Publicado no:Sci Rep
Main Authors: Lesterhuis, W. Joost, Rinaldi, Catherine, Jones, Anya, Rozali, Esdy N., Dick, Ian M., Khong, Andrea, Boon, Louis, Robinson, Bruce W., Nowak, Anna K., Bosco, Anthony, Lake, Richard A.
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2015
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4508665/
https://ncbi.nlm.nih.gov/pubmed/26193793
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep12298
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