Restoration of defective cross-presentation in tumors by gemcitabine

Tumor antigen cross-presentation by dendritic cells (DCs) to specific CD8(+) T cells is central to antitumor immunity. Although highly efficient in draining lymph nodes, it is defective within the tumor site itself. Importantly, an immunogenic chemotherapy, gemcitabine, reverses this defect, allowin...

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Bibliografiske detaljer
Udgivet i:Oncoimmunology
Main Authors: McDonnell, Alison M, Joost Lesterhuis, W, Khong, Andrea, Nowak, Anna K, Lake, Richard A, Currie, Andrew J, Robinson, Bruce WS
Format: Artigo
Sprog:Inglês
Udgivet: Taylor & Francis 2015
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Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4485774/
https://ncbi.nlm.nih.gov/pubmed/26155402
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/2162402X.2015.1005501
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