Whole-Exome Sequencing of Metastatic Cancer and Biomarkers of Treatment Response

IMPORTANCE: Understanding molecular mechanisms of response and resistance to anticancer therapies requires prospective patient follow-up and clinical and functional validation of both common and low-frequency mutations. We describe a whole-exome sequencing (WES) precision medicine trial focused on p...

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Publicat a:JAMA Oncol
Autors principals: Beltran, Himisha, Eng, Kenneth, Mosquera, Juan Miguel, Sigaras, Alexandros, Romanel, Alessandro, Rennert, Hanna, Kossai, Myriam, Pauli, Chantal, Faltas, Bishoy, Fontugne, Jacqueline, Park, Kyung, Banfelder, Jason, Prandi, Davide, Madhukar, Neel, Zhang, Tuo, Padilla, Jessica, Greco, Noah, McNary, Terra J., Herrscher, Erick, Wilkes, David, MacDonald, Theresa Y., Xue, Hui, Vacic, Vladimir, Emde, Anne-Katrin, Oschwald, Dayna, Tan, Adrian Y., Chen, Zhengming, Collins, Colin, Gleave, Martin E., Wang, Yuzhuo, Chakravarty, Dimple, Schiffman, Marc, Kim, Robert, Campagne, Fabien, Robinson, Brian D., Nanus, David M., Tagawa, Scott T., Xiang, Jenny Z., Smogorzewska, Agata, Demichelis, Francesca, Rickman, David S., Sboner, Andrea, Elemento, Olivier, Rubin, Mark A.
Format: Artigo
Idioma:Inglês
Publicat: 2015
Matèries:
Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4505739/
https://ncbi.nlm.nih.gov/pubmed/26181256
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1001/jamaoncol.2015.1313
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