Whole-Exome Sequencing of Metastatic Cancer and Biomarkers of Treatment Response

IMPORTANCE: Understanding molecular mechanisms of response and resistance to anticancer therapies requires prospective patient follow-up and clinical and functional validation of both common and low-frequency mutations. We describe a whole-exome sequencing (WES) precision medicine trial focused on p...

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Pubblicato in:JAMA Oncol
Autori principali: Beltran, Himisha, Eng, Kenneth, Mosquera, Juan Miguel, Sigaras, Alexandros, Romanel, Alessandro, Rennert, Hanna, Kossai, Myriam, Pauli, Chantal, Faltas, Bishoy, Fontugne, Jacqueline, Park, Kyung, Banfelder, Jason, Prandi, Davide, Madhukar, Neel, Zhang, Tuo, Padilla, Jessica, Greco, Noah, McNary, Terra J., Herrscher, Erick, Wilkes, David, MacDonald, Theresa Y., Xue, Hui, Vacic, Vladimir, Emde, Anne-Katrin, Oschwald, Dayna, Tan, Adrian Y., Chen, Zhengming, Collins, Colin, Gleave, Martin E., Wang, Yuzhuo, Chakravarty, Dimple, Schiffman, Marc, Kim, Robert, Campagne, Fabien, Robinson, Brian D., Nanus, David M., Tagawa, Scott T., Xiang, Jenny Z., Smogorzewska, Agata, Demichelis, Francesca, Rickman, David S., Sboner, Andrea, Elemento, Olivier, Rubin, Mark A.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2015
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4505739/
https://ncbi.nlm.nih.gov/pubmed/26181256
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1001/jamaoncol.2015.1313
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