Pharmacologic inhibition of the NLRP3 inflammasome preserves cardiac function after ischemic and non-ischemic injury in the mouse

BACKGROUND: Sterile inflammation resulting from myocardial injury activates the NLRP3 inflammasome and amplifies the inflammatory response mediating further damage. METHODS: We used two experimental models of ischemic injury (acute myocardial infarction [AMI] with and without reperfusion) and a mode...

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Gepubliceerd in:J Cardiovasc Pharmacol
Hoofdauteurs: Marchetti, Carlo, Toldo, Stefano, Chojnacki, Jeremy, Mezzaroma, Eleonora, Liu, Kai, Salloum, Fadi N., Nordio, Andrea, Carbone, Salvatore, Mauro, Adolfo Gabriele, Das, Anindita, Zalavadia, Ankit A., Halquist, Matthew S., Federici, Massimo, Van Tassell, Benjamin W., Zhang, Shijun, Abbate, Antonio
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: 2015
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Article
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4500673/
https://ncbi.nlm.nih.gov/pubmed/25915511
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1097/FJC.0000000000000247
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