BF(3)·OEt(2)-Promoted Concise Synthesis of Difluoroboron-Derivatized Curcumins from Aldehydes and 2,4-Pentanedione

Por Liu, Kai, Chen, Jiangmin, Chojnacki, Jeremy, Zhang, Shijun
Publicado em 2013

Bivalent ligands incorporating curcumin and diosgenin as multifunctional compounds against Alzheimer’s disease

Por Chojnacki, Jeremy E., Liu, Kai, Saathoff, John M., Zhang, Shijun
Publicado no Bioorg Med Chem (2015)

NLRP3 inflammasome inhibitor ameliorates amyloid pathology in a mouse model of Alzheimer’s disease

Por Yin, Jun, Zhao, Fanpeng, Chojnacki, Jeremy E., Fulp, Jacob, Klein, William L., Zhang, Shijun, Zhu, Xiongwei
Publicado no Mol Neurobiol (2017)

Mechanistic Insight of Bivalent Compound 21MO as Potential Neuroprotectant for Alzheimer’s Disease

Por Saathoff, John M., Liu, Kai, Chojnacki, Jeremy E., He, Liu, Chen, Qun, Lesnefsky, Edward J., Zhang, Shijun
Publicado no Molecules (2016)

Bivalent compound 17MN exerts neuroprotection through interaction at multiple sites in a cellular model of Alzheimer’s disease

Por Liu, Kai, Chojnacki, Jeremy E., Wade, Emily E., Saathoff, John M., Lesnefsky, Edward J., Chen, Qun, Zhang, Shijun
Publicado no J Alzheimers Dis (2015)

Development and Characterization of a Hydroxyl-Sulfonamide Analogue, 5-Chloro-N-[2-(4-hydroxysulfamoyl-phenyl)-ethyl]-2-methoxy-benzamide, as a Novel NLRP3 Inflammasome Inhibitor f...

Por Guo, Chunqing, Fulp, Jacob W., Jiang, Yuqi, Li, Xia, Chojnacki, Jeremy E., Wu, Jingde, Wang, Xiang-Yang, Zhang, Shijun
Publicado no ACS Chem Neurosci (2017)

Bivalent Ligand Containing Curcumin and Cholesterol as a Fluorescence Probe for Aβ Plaques in Alzheimer’s Disease

Por Liu, Kai, Guo, Tai L., Chojnacki, Jeremy, Lee, Hyoung-Gon, Wang, Xinglong, Siedlak, Sandra L., Rao, Wei, Zhu, Xiongwei, Zhang, Shijun
Publicado em 2011

A curcumin/melatonin hybrid, 5-(4-hydroxy-phenyl)-3-oxo-pentanoic acid [2-(5-methoxy-1H-indol-3-yl)-ethyl]-amide, ameliorates AD-like pathology in the APP/PS1 mouse model

Por Gerenu, Gorka, Liu, Kai, Chojnacki, Jeremy E., Saathoff, John M., Martínez-Martín, Pablo, Perry, George, Zhu, Xiongwei, Lee, Hyoung-gon, Zhang, Shijun
Publicado no ACS Chem Neurosci (2015)

A NOVEL PHARMACOLOGIC INHIBITOR OF THE NLRP3 INFLAMMASOME LIMITS MYOCARDIAL INJURY FOLLOWING ISCHEMIA-REPERFUSION IN THE MOUSE

Por Marchetti, Carlo, Chojnacki, Jeremy, Toldo, Stefano, Mezzaroma, Eleonora, Tranchida, Nicla, Rose, Scott W., Federici, Massimo, Van Tassell, Benjamin W., Zhang, Shijun, Abbate, Antonio
Publicado em 2014

Discovery of 5-(4-Hydroxyphenyl)-3-oxo-pentanoic Acid [2-(5-Methoxy-1H-indol-3-yl)-ethyl]-amide as a Neuroprotectant for Alzheimer’s Disease by Hybridization of Curcumin and Melato...

Por Chojnacki, Jeremy E., Liu, Kai, Yan, Xing, Toldo, Stefano, Selden, Tyler, Estrada, Martin, Rodríguez-Franco, María Isabel, Halquist, Matthew S., Ye, Dexian, Zhang, Shijun
Publicado em 2014

Pharmacologic inhibition of the NLRP3 inflammasome preserves cardiac function after ischemic and non-ischemic injury in the mouse

Por Marchetti, Carlo, Toldo, Stefano, Chojnacki, Jeremy, Mezzaroma, Eleonora, Liu, Kai, Salloum, Fadi N., Nordio, Andrea, Carbone, Salvatore, Mauro, Adolfo Gabriele, Das, Anindita, Zalavadia, Ankit A., Halquist, Matthew S., Federici, Massimo, Van Tassell, Benjamin W., Zhang, Shijun, Abbate, Antonio
Publicado no J Cardiovasc Pharmacol (2015)