A NOVEL PHARMACOLOGIC INHIBITOR OF THE NLRP3 INFLAMMASOME LIMITS MYOCARDIAL INJURY FOLLOWING ISCHEMIA-REPERFUSION IN THE MOUSE

BACKGROUND: The formation of the NLRP3 inflammasome in the heart during AMI amplifies the inflammatory response and mediates further damage. Glyburide has NLRP3-inhibitory activity in vitro, but requires very high doses in vivo, associated with hypoglycemia. The aim of this study was to measure the...

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Detalhes bibliográficos
Main Authors: Marchetti, Carlo, Chojnacki, Jeremy, Toldo, Stefano, Mezzaroma, Eleonora, Tranchida, Nicla, Rose, Scott W., Federici, Massimo, Van Tassell, Benjamin W., Zhang, Shijun, Abbate, Antonio
Formato: Artigo
Idioma:Inglês
Publicado em: 2014
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3980088/
https://ncbi.nlm.nih.gov/pubmed/24336017
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1097/FJC.0000000000000053
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