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NLRP3 inflammasome inhibitor ameliorates amyloid pathology in a mouse model of Alzheimer’s disease

The activation of the NLRP3 inflammasome signaling pathway plays an important role in the neuroinflammation in Alzheimer’s disease (AD). In this study, we investigated the effects of JC-124, a rationally designed NLRP3 inflammasome inhibitor, on AD-related deficits in CRND8 APP transgenic mice (TgCR...

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Détails bibliographiques
Publié dans:Mol Neurobiol
Auteurs principaux: Yin, Jun, Zhao, Fanpeng, Chojnacki, Jeremy E., Fulp, Jacob, Klein, William L., Zhang, Shijun, Zhu, Xiongwei
Format: Artigo
Langue:Inglês
Publié: 2017
Sujets:
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC5585057/
https://ncbi.nlm.nih.gov/pubmed/28255908
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s12035-017-0467-9
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