Structural Insights of Benzenesulfonamide Analogues as NLRP3 Inflammasome Inhibitors: Design, Synthesis, and Biological Characterization

NLRP3 inflammasome plays critical roles in a variety of human diseases and represents a promising drug target. In this study, we established the in vivo functional activities of JC124, a previously identified NLRP3 inflamma-some inhibitor from our group, in mouse models of Alzheimer’s disease and ac...

Celý popis

Uloženo v:
Podrobná bibliografie
Vydáno v:J Med Chem
Hlavní autoři: Fulp, Jacob, He, Liu, Toldo, Stefano, Jiang, Yuqi, Boice, Ashley, Guo, Chunqing, Li, Xia, Rolfe, Andrew, Sun, Dong, Abbate, Antonio, Wang, Xiang-Yang, Zhang, Shijun
Médium: Artigo
Jazyk:Inglês
Vydáno: 2018
Témata:
Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6225534/
https://ncbi.nlm.nih.gov/pubmed/29877709
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.jmedchem.8b00733
Tagy: Přidat tag
Žádné tagy, Buďte první, kdo otaguje tento záznam!

Podobné jednotky