Structural Insights of Benzenesulfonamide Analogues as NLRP3 Inflammasome Inhibitors: Design, Synthesis, and Biological Characterization

NLRP3 inflammasome plays critical roles in a variety of human diseases and represents a promising drug target. In this study, we established the in vivo functional activities of JC124, a previously identified NLRP3 inflamma-some inhibitor from our group, in mouse models of Alzheimer’s disease and ac...

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Detaylı Bibliyografya
Yayımlandı:J Med Chem
Asıl Yazarlar: Fulp, Jacob, He, Liu, Toldo, Stefano, Jiang, Yuqi, Boice, Ashley, Guo, Chunqing, Li, Xia, Rolfe, Andrew, Sun, Dong, Abbate, Antonio, Wang, Xiang-Yang, Zhang, Shijun
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: 2018
Konular:
Article
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC6225534/
https://ncbi.nlm.nih.gov/pubmed/29877709
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.jmedchem.8b00733
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