Discovery of second-generation NLRP3 inflammasome inhibitors: Design, synthesis, and biological characterization

NLRP3 inflammasome has recently emerged as an attractive drug target for neurodegenerative disorders. In our continuing studies, a new chemical scaffold was designed as selective inhibitors of NLRP3 inflammasome. Initial characterization of the lead HL16 demonstrated improved however non-selective i...

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Detaylı Bibliyografya
Yayımlandı:J Med Chem
Asıl Yazarlar: Jiang, Yuqi, He, Liu, Green, Jakob, Blevins, Hallie, Guo, Chunqing, Patel, Sulay Harsiddhbhai, Halquist, Matthew S., McRae, MaryPeace, Venitz, Jürgen, Wang, Xiang-Yang, Zhang, Shijun
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: 2019
Konular:
Article
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC6856409/
https://ncbi.nlm.nih.gov/pubmed/31626545
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.jmedchem.9b01155
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