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Discovery of second-generation NLRP3 inflammasome inhibitors: Design, synthesis, and biological characterization
NLRP3 inflammasome has recently emerged as an attractive drug target for neurodegenerative disorders. In our continuing studies, a new chemical scaffold was designed as selective inhibitors of NLRP3 inflammasome. Initial characterization of the lead HL16 demonstrated improved however non-selective i...
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| Publicado en: | J Med Chem |
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| Main Authors: | , , , , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
2019
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| Assuntos: | |
| Acceso en liña: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6856409/ https://ncbi.nlm.nih.gov/pubmed/31626545 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.jmedchem.9b01155 |
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