Preservation of Contractile Reserve and Diastolic Function by Inhibiting the NLRP3 Inflammasome with OLT1177(®) (Dapansutrile) in a Mouse Model of Severe Ischemic Cardiomyopathy Due to Non-Reperfused Anterior Wall Myocardial Infarction

Interleukin-1β (IL-1β), a product of the NLRP3 inflammasome, modulates cardiac contractility and diastolic function. We proposed that OLT1177(®) (dapansutrile), a novel NLRP3 inhibitor, could preserve contractile reserve and diastolic function after myocardial infarction (MI). We used an experimenta...

Descrición completa

Gardado en:
Detalles Bibliográficos
Publicado en:Molecules
Main Authors: Aliaga, Joseph, Bonaventura, Aldo, Mezzaroma, Eleonora, Dhakal, Yogesh, Mauro, Adolfo Gabriele, Abbate, Antonio, Toldo, Stefano
Formato: Artigo
Idioma:Inglês
Publicado: MDPI 2021
Assuntos:
Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC8227554/
https://ncbi.nlm.nih.gov/pubmed/34207886
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/molecules26123534
Tags: Engadir etiqueta
Sen Etiquetas, Sexa o primeiro en etiquetar este rexistro!

Títulos similares