An Orally Available NLRP3 Inflammasome Inhibitor Prevents Western Diet–Induced Cardiac Dysfunction in Mice

BACKGROUND: A diet rich in saturated fat and sugars (Western diet, WD) induces myocardial expression of the NLRP3 inflammasome and dysfunction in mice. We therefore hypothesized that a diet enriched with an orally available NLRP3 inflammasome inhibitor could prevent WD-induced cardiac dysfunction in...

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Bibliografske podrobnosti
izdano v:J Cardiovasc Pharmacol
Main Authors: Carbone, Salvatore, Mauro, Adolfo G., Prestamburgo, Andrea, Halquist, Matthew S., Narayan, Pratush, Potere, Nicola, Mezzaroma, Eleonora, Van Tassell, Benjamin W., Abbate, Antonio, Toldo, Stefano
Format: Artigo
Jezik:Inglês
Izdano: 2018
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Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC6511457/
https://ncbi.nlm.nih.gov/pubmed/30422890
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1097/FJC.0000000000000628
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