HIV Neutralizing Antibodies Induced by Native-like Envelope Trimers

A challenge for HIV-1 immunogen design is inducing neutralizing antibodies (NAbs) against neutralization-resistant (Tier-2) viruses that dominate human transmissions. We show that a soluble recombinant HIV-1 envelope glycoprotein trimer that adopts a native conformation (BG505 SOSIP.664) induced NAb...

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Bibliografske podrobnosti
izdano v:Science
Main Authors: Sanders, Rogier W., van Gils, Marit J., Derking, Ronald, Sok, Devin, Ketas, Thomas J., Burger, Judith A., Ozorowski, Gabriel, Cupo, Albert, Simonich, Cassandra, Goo, Leslie, Arendt, Heather, Kim, Helen J., Lee, Jeong Hyun, Pugach, Pavel, Williams, Melissa, Debnath, Gargi, Moldt, Brian, van Breemen, Mariëlle J., Isik, Gözde, Medina-Ramírez, Max, Back, Jaap Willem, Koff, Wayne, Julien, Jean-Philippe, Rakasz, Eva G., Seaman, Michael S., Guttman, Miklos, Lee, Kelly K., Klasse, Per Johan, LaBranche, Celia, Schief, William R., Wilson, Ian A., Overbaugh, Julie, Burton, Dennis R., Ward, Andrew B., Montefiori, David C., Dean, Hansi, Moore, John P.
Format: Artigo
Jezik:Inglês
Izdano: 2015
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Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC4498988/
https://ncbi.nlm.nih.gov/pubmed/26089353
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/science.aac4223
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