Autoimmunity-associated protein tyrosine phosphatase PEP negatively regulates IFN-α receptor signaling

The protein tyrosine phosphatase PTPN22(C1858T) allelic polymorphism is associated with increased susceptibility for development of systemic lupus erythematosus (SLE) and other autoimmune diseases. PTPN22 (also known as LYP) and its mouse orthologue PEP play important roles in antigen and Toll-like...

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Vydáno v:J Exp Med
Hlavní autoři: Holmes, Derek A., Suto, Eric, Lee, Wyne P., Ou, Qinglin, Gong, Qian, Smith, Hamish R.C., Caplazi, Patrick, Chan, Andrew C.
Médium: Artigo
Jazyk:Inglês
Vydáno: The Rockefeller University Press 2015
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4493413/
https://ncbi.nlm.nih.gov/pubmed/26077719
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20142130
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