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Autoimmunity-associated protein tyrosine phosphatase PEP negatively regulates IFN-α receptor signaling

The protein tyrosine phosphatase PTPN22(C1858T) allelic polymorphism is associated with increased susceptibility for development of systemic lupus erythematosus (SLE) and other autoimmune diseases. PTPN22 (also known as LYP) and its mouse orthologue PEP play important roles in antigen and Toll-like...

詳細記述

保存先:
書誌詳細
出版年:J Exp Med
主要な著者: Holmes, Derek A., Suto, Eric, Lee, Wyne P., Ou, Qinglin, Gong, Qian, Smith, Hamish R.C., Caplazi, Patrick, Chan, Andrew C.
フォーマット: Artigo
言語:Inglês
出版事項: The Rockefeller University Press 2015
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC4493413/
https://ncbi.nlm.nih.gov/pubmed/26077719
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20142130
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