Autoimmunity linked protein phosphatase PTPN22 as a target for cancer immunotherapy

BACKGROUND: Cancer immunotherapy has evolved from interferon-alpha (IFNα) and interleukin-2 in the 1980s to CTLA-4 and PD-1/PD-L1 checkpoint inhibitors (CPIs), the latter highlighting the importance of enhancing T-cell functions. While the search for novel immunomodulatory pathways continues, combin...

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Detalhes bibliográficos
Publicado no:J Immunother Cancer
Main Authors: Cubas, Rafael, Khan, Zia, Gong, Qian, Moskalenko, Marina, Xiong, Huizhong, Ou, Qinglin, Pai, Christine, Rodriguez, Ryan, Cheung, Jeanne, Chan, Andrew C
Formato: Artigo
Idioma:Inglês
Publicado em: BMJ Publishing Group 2020
Assuntos:
Basic Tumor Immunology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7604869/
https://ncbi.nlm.nih.gov/pubmed/33127657
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1136/jitc-2020-001439
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