Autoimmunity-associated protein tyrosine phosphatase PEP negatively regulates IFN-α receptor signaling

The protein tyrosine phosphatase PTPN22(C1858T) allelic polymorphism is associated with increased susceptibility for development of systemic lupus erythematosus (SLE) and other autoimmune diseases. PTPN22 (also known as LYP) and its mouse orthologue PEP play important roles in antigen and Toll-like...

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Detalhes bibliográficos
Publicado no:J Exp Med
Main Authors: Holmes, Derek A., Suto, Eric, Lee, Wyne P., Ou, Qinglin, Gong, Qian, Smith, Hamish R.C., Caplazi, Patrick, Chan, Andrew C.
Formato: Artigo
Idioma:Inglês
Publicado em: The Rockefeller University Press 2015
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4493413/
https://ncbi.nlm.nih.gov/pubmed/26077719
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20142130
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