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Autoimmunity-associated protein tyrosine phosphatase PEP negatively regulates IFN-α receptor signaling
The protein tyrosine phosphatase PTPN22(C1858T) allelic polymorphism is associated with increased susceptibility for development of systemic lupus erythematosus (SLE) and other autoimmune diseases. PTPN22 (also known as LYP) and its mouse orthologue PEP play important roles in antigen and Toll-like...
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| Publié dans: | J Exp Med |
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| Auteurs principaux: | , , , , , , , |
| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
The Rockefeller University Press
2015
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| Sujets: | |
| Accès en ligne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4493413/ https://ncbi.nlm.nih.gov/pubmed/26077719 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20142130 |
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