Potent and Selective Triazole-Based Inhibitors of the Hypoxia-Inducible Factor Prolyl-Hydroxylases with Activity in the Murine Brain

As part of the cellular adaptation to limiting oxygen availability in animals, the expression of a large set of genes is activated by the upregulation of the hypoxia-inducible transcription factors (HIFs). Therapeutic activation of the natural human hypoxic response can be achieved by the inhibition...

詳細記述

保存先:
書誌詳細
出版年:PLoS One
主要な著者: Chan, Mun Chiang, Atasoylu, Onur, Hodson, Emma, Tumber, Anthony, Leung, Ivanhoe K. H., Chowdhury, Rasheduzzaman, Gómez-Pérez, Verónica, Demetriades, Marina, Rydzik, Anna M., Holt-Martyn, James, Tian, Ya-Min, Bishop, Tammie, Claridge, Timothy D. W., Kawamura, Akane, Pugh, Christopher W., Ratcliffe, Peter J., Schofield, Christopher J.
フォーマット: Artigo
言語:Inglês
出版事項: Public Library of Science 2015
主題:
Research Article
オンライン･アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC4492579/
https://ncbi.nlm.nih.gov/pubmed/26147748
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0132004
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