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Growth factor identity is encoded by discrete coiled coil rotamers in the EGFR juxtamembrane region

Binding of the growth factor TGF-α to the EGFR extracellular domain is encoded through the formation of a unique anti-parallel coiled coil within the juxtamembrane segment. This new coiled coil is an ‘inside-out’ version of the coiled coil formed in the presence of EGF. A third, intermediary coiled...

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Publicado en:Chem Biol
Autores principales: Doerner, Amy, Scheck, Rebecca, Schepartz, Alanna
Formato: Artigo
Lenguaje:Inglês
Publicado: 2015
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Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC4487654/
https://ncbi.nlm.nih.gov/pubmed/26091170
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.chembiol.2015.05.008
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