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Structural differences between wild type and double mutant EGFR modulated by third-generation kinase inhibitors

Mutations in the EGFR kinase domain are implicated in non-small cell lung cancer. Of particular interest is the drug-resistant double mutant (L858R/T790M, DM EGFR), which is not inhibited selectively by any approved kinase inhibitor. Here we apply bipartite tetracysteine display to demonstrate that...

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Bibliografiske detaljer
Udgivet i:J Am Chem Soc
Main Authors: Lowder, Melissa A., Doerner, Amy E., Schepartz, Alanna
Format: Artigo
Sprog:Inglês
Udgivet: 2015
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4638123/
https://ncbi.nlm.nih.gov/pubmed/25973741
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jacs.5b02326
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