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Structural differences between wild type and double mutant EGFR modulated by third-generation kinase inhibitors
Mutations in the EGFR kinase domain are implicated in non-small cell lung cancer. Of particular interest is the drug-resistant double mutant (L858R/T790M, DM EGFR), which is not inhibited selectively by any approved kinase inhibitor. Here we apply bipartite tetracysteine display to demonstrate that...
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| Udgivet i: | J Am Chem Soc |
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| Main Authors: | , , |
| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
2015
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4638123/ https://ncbi.nlm.nih.gov/pubmed/25973741 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jacs.5b02326 |
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