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Discrete Coiled Coil Rotamers Form within the EGFRvIII Juxtamembrane Domain

Mutations in the epidermal growth factor receptor (EGFR) extracellular domain (ECD) are implicated in the development of glioblastoma multiforme (GBM), which is a highly aggressive form of brain cancer. Of particular interest to GBM is the EGFR variant known as EGFRvIII, which is distinguished by an...

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Vydáno v:Biochemistry
Hlavní autoři: Mozumdar, Deepto, Doerner, Amy, Zhang, Justin Y., Rafizadeh, Diane N., Schepartz, Alanna
Médium: Artigo
Jazyk:Inglês
Vydáno: 2020
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7906117/
https://ncbi.nlm.nih.gov/pubmed/32941004
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.biochem.0c00641
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