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Mechanism of allosteric coupling into and through the plasma membrane by EGFR

EGFR interacts through its extracellular domain (ECD) with seven different growth factors. These factors induce different structures within the cytoplasmic juxtamembrane segment (JM) of the dimeric receptor and propagate different growth factor-dependent signals to the cell interior. How this proces...

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Publicat a:Cell Chem Biol
Autors principals: Sinclair, Julie K.L., Walker, Allison S., Doerner, Amy E., Schepartz, Alanna
Format: Artigo
Idioma:Inglês
Publicat: 2018
Matèries:
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6054568/
https://ncbi.nlm.nih.gov/pubmed/29731426
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.chembiol.2018.04.005
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