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Mechanism of allosteric coupling into and through the plasma membrane by EGFR

EGFR interacts through its extracellular domain (ECD) with seven different growth factors. These factors induce different structures within the cytoplasmic juxtamembrane segment (JM) of the dimeric receptor and propagate different growth factor-dependent signals to the cell interior. How this proces...

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Detalhes bibliográficos
Publicado no:Cell Chem Biol
Main Authors: Sinclair, Julie K.L., Walker, Allison S., Doerner, Amy E., Schepartz, Alanna
Formato: Artigo
Idioma:Inglês
Publicado em: 2018
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6054568/
https://ncbi.nlm.nih.gov/pubmed/29731426
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.chembiol.2018.04.005
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