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Bipartite Tetracysteine Display Reveals Allosteric Control of Ligand-Specific EGFR Activation
Aberrant activation of the epidermal growth factor receptor (EGFR) is critical to the biology of many common cancers. The molecular events that define how EGFR transmits an extracellular ligand binding event through the membrane are not understood. Here we use a chemical tool, bipartite tetracystein...
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| Main Authors: | , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2012
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3789377/ https://ncbi.nlm.nih.gov/pubmed/22667988 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/cb300216f |
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