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Bipartite Tetracysteine Display Reveals Allosteric Control of Ligand-Specific EGFR Activation

Aberrant activation of the epidermal growth factor receptor (EGFR) is critical to the biology of many common cancers. The molecular events that define how EGFR transmits an extracellular ligand binding event through the membrane are not understood. Here we use a chemical tool, bipartite tetracystein...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Prif Awduron: Scheck, Rebecca A., Lowder, Melissa A., Appelbaum, Jacob S., Schepartz, Alanna
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: 2012
Pynciau:
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC3789377/
https://ncbi.nlm.nih.gov/pubmed/22667988
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/cb300216f
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