Active Site and Remote Contributions to Catalysis in Methylthioadenosine Nucleosidases

5′-Methylthioadenosine/S-adenosyl-L-homocysteine nucleosidases (MTANs) catalyze the hydrolysis of 5′-methylthioadenosine to adenine and 5-methylthioribose. The amino acid sequences of the MTANs from Vibrio cholerae (VcMTAN) and Escherichia coli (EcMTAN) are 60% identical and 75% similar. Protein str...

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Bibliografiske detaljer
Udgivet i:Biochemistry
Main Authors: Thomas, Keisha, Cameron, Scott A., Almo, Steven C., Burgos, Emmanuel S., Gulab, Shivali A., Schramm, Vern L.
Format: Artigo
Sprog:Inglês
Udgivet: 2015
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4485437/
https://ncbi.nlm.nih.gov/pubmed/25806409
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bi501487w
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