Repression of SRF target genes is critical for Myc-dependent apoptosis of epithelial cells

Oncogenic levels of Myc expression sensitize cells to multiple apoptotic stimuli, and this protects long-lived organisms from cancer development. How cells discriminate physiological from supraphysiological levels of Myc is largely unknown. Here, we show that induction of apoptosis by Myc in breast...

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Bibliographic Details
Published in:EMBO J
Main Authors: Wiese, Katrin E, Haikala, Heidi M, von Eyss, Björn, Wolf, Elmar, Esnault, Cyril, Rosenwald, Andreas, Treisman, Richard, Klefström, Juha, Eilers, Martin
Format: Artigo
Language:Inglês
Published: BlackWell Publishing Ltd 2015
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Articles
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4474530/
https://ncbi.nlm.nih.gov/pubmed/25896507
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.15252/embj.201490467
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