Dominant Suppression of Inflammation via Targeted Mutation of the mRNA Destabilizing Protein Tristetraprolin

In myeloid cells, the mRNA-destabilizing protein tristetraprolin (TTP) is induced and extensively phosphorylated in response to LPS. To investigate the role of two specific phosphorylations, at serines 52 and 178, we created a mouse strain in which those residues were replaced by nonphosphorylatable...

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Pubblicato in:J Immunol
Autori principali: Ross, Ewan A., Smallie, Tim, Ding, Qize, O’Neil, John D., Cunliffe, Helen E., Tang, Tina, Rosner, Dalya R., Klevernic, Iva, Morrice, Nicholas A., Monaco, Claudia, Cunningham, Adam F., Buckley, Christopher D., Saklatvala, Jeremy, Dean, Jonathan L., Clark, Andrew R.
Natura: Artigo
Lingua:Inglês
Pubblicazione: AAI 2015
Soggetti:
Innate Immunity and Inflammation
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4472942/
https://ncbi.nlm.nih.gov/pubmed/26002976
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.1402826
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