Dominant Suppression of Inflammation via Targeted Mutation of the mRNA Destabilizing Protein Tristetraprolin

In myeloid cells, the mRNA-destabilizing protein tristetraprolin (TTP) is induced and extensively phosphorylated in response to LPS. To investigate the role of two specific phosphorylations, at serines 52 and 178, we created a mouse strain in which those residues were replaced by nonphosphorylatable...

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Vydáno v:J Immunol
Hlavní autoři: Ross, Ewan A., Smallie, Tim, Ding, Qize, O’Neil, John D., Cunliffe, Helen E., Tang, Tina, Rosner, Dalya R., Klevernic, Iva, Morrice, Nicholas A., Monaco, Claudia, Cunningham, Adam F., Buckley, Christopher D., Saklatvala, Jeremy, Dean, Jonathan L., Clark, Andrew R.
Médium: Artigo
Jazyk:Inglês
Vydáno: AAI 2015
Témata:
Innate Immunity and Inflammation
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4472942/
https://ncbi.nlm.nih.gov/pubmed/26002976
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.1402826
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