Dominant Suppression of Inflammation via Targeted Mutation of the mRNA Destabilizing Protein Tristetraprolin

In myeloid cells, the mRNA-destabilizing protein tristetraprolin (TTP) is induced and extensively phosphorylated in response to LPS. To investigate the role of two specific phosphorylations, at serines 52 and 178, we created a mouse strain in which those residues were replaced by nonphosphorylatable...

Fuld beskrivelse

Na minha lista:
Bibliografiske detaljer
Udgivet i:J Immunol
Main Authors: Ross, Ewan A., Smallie, Tim, Ding, Qize, O’Neil, John D., Cunliffe, Helen E., Tang, Tina, Rosner, Dalya R., Klevernic, Iva, Morrice, Nicholas A., Monaco, Claudia, Cunningham, Adam F., Buckley, Christopher D., Saklatvala, Jeremy, Dean, Jonathan L., Clark, Andrew R.
Format: Artigo
Sprog:Inglês
Udgivet: AAI 2015
Fag:
Innate Immunity and Inflammation
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4472942/
https://ncbi.nlm.nih.gov/pubmed/26002976
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.1402826
Tags: Tilføj Tag
Ingen Tags, Vær først til at tagge denne postø!

Lignende værker