Dominant Suppression of Inflammation via Targeted Mutation of the mRNA Destabilizing Protein Tristetraprolin

In myeloid cells, the mRNA-destabilizing protein tristetraprolin (TTP) is induced and extensively phosphorylated in response to LPS. To investigate the role of two specific phosphorylations, at serines 52 and 178, we created a mouse strain in which those residues were replaced by nonphosphorylatable...

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Xehetasun bibliografikoak
Argitaratua izan da:J Immunol
Egile Nagusiak: Ross, Ewan A., Smallie, Tim, Ding, Qize, O’Neil, John D., Cunliffe, Helen E., Tang, Tina, Rosner, Dalya R., Klevernic, Iva, Morrice, Nicholas A., Monaco, Claudia, Cunningham, Adam F., Buckley, Christopher D., Saklatvala, Jeremy, Dean, Jonathan L., Clark, Andrew R.
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: AAI 2015
Gaiak:
Innate Immunity and Inflammation
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC4472942/
https://ncbi.nlm.nih.gov/pubmed/26002976
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.1402826
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