Gain-of-Function Mutation of Tristetraprolin Impairs Negative Feedback Control of Macrophages In Vitro yet Has Overwhelmingly Anti-Inflammatory Consequences In Vivo

The mRNA-destabilizing factor tristetraprolin (TTP) binds in a sequence-specific manner to the 3′ untranslated regions of many proinflammatory mRNAs and recruits complexes of nucleases to promote rapid mRNA turnover. Mice lacking TTP develop a severe, spontaneous inflammatory syndrome characterized...

Deskribapen osoa

Gorde:
Xehetasun bibliografikoak
Argitaratua izan da:Mol Cell Biol
Egile Nagusiak: O'Neil, John D., Ross, Ewan A., Ridley, Michael L., Ding, Qize, Tang, Tina, Rosner, Dalya R., Crowley, Thomas, Malhi, Deepak, Dean, Jonathan L., Smallie, Tim, Buckley, Christopher D., Clark, Andrew R.
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: American Society for Microbiology 2017
Gaiak:
Research Article
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC5440651/
https://ncbi.nlm.nih.gov/pubmed/28265004
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.00536-16
Etiketak: Etiketa erantsi
Etiketarik gabe, Izan zaitez lehena erregistro honi etiketa jartzen!

Antzeko izenburuak