Dual-Specificity Phosphatase 1 and Tristetraprolin Cooperate To Regulate Macrophage Responses to Lipopolysaccharide

Dual-specificity phosphatase (DUSP) 1 dephosphorylates and inactivates members of the MAPK superfamily, in particular, JNKs, p38α, and p38β MAPKs. It functions as an essential negative regulator of innate immune responses, hence disruption of the Dusp1 gene renders mice extremely sensitive to a wide...

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Detalhes bibliográficos
Publicado no:J Immunol
Main Authors: Smallie, Tim, Ross, Ewan A., Ammit, Alaina J., Cunliffe, Helen E., Tang, Tina, Rosner, Dalya R., Ridley, Michael L., Buckley, Christopher D., Saklatvala, Jeremy, Dean, Jonathan L., Clark, Andrew R.
Formato: Artigo
Idioma:Inglês
Publicado em: AAI 2015
Assuntos:
Innate Immunity and Inflammation
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4472943/
https://ncbi.nlm.nih.gov/pubmed/26019272
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.1402830
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