Dual-Specificity Phosphatase 1 and Tristetraprolin Cooperate To Regulate Macrophage Responses to Lipopolysaccharide

Dual-specificity phosphatase (DUSP) 1 dephosphorylates and inactivates members of the MAPK superfamily, in particular, JNKs, p38α, and p38β MAPKs. It functions as an essential negative regulator of innate immune responses, hence disruption of the Dusp1 gene renders mice extremely sensitive to a wide...

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Dades bibliogràfiques
Publicat a:J Immunol
Autors principals: Smallie, Tim, Ross, Ewan A., Ammit, Alaina J., Cunliffe, Helen E., Tang, Tina, Rosner, Dalya R., Ridley, Michael L., Buckley, Christopher D., Saklatvala, Jeremy, Dean, Jonathan L., Clark, Andrew R.
Format: Artigo
Idioma:Inglês
Publicat: AAI 2015
Matèries:
Innate Immunity and Inflammation
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4472943/
https://ncbi.nlm.nih.gov/pubmed/26019272
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.1402830
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