Dual-Specificity Phosphatase 1 and Tristetraprolin Cooperate To Regulate Macrophage Responses to Lipopolysaccharide

Dual-specificity phosphatase (DUSP) 1 dephosphorylates and inactivates members of the MAPK superfamily, in particular, JNKs, p38α, and p38β MAPKs. It functions as an essential negative regulator of innate immune responses, hence disruption of the Dusp1 gene renders mice extremely sensitive to a wide...

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Bibliographic Details
Published in:	J Immunol
Main Authors:	Smallie, Tim, Ross, Ewan A., Ammit, Alaina J., Cunliffe, Helen E., Tang, Tina, Rosner, Dalya R., Ridley, Michael L., Buckley, Christopher D., Saklatvala, Jeremy, Dean, Jonathan L., Clark, Andrew R.
Format:	Artigo
Language:	Inglês
Published:	AAI 2015
Subjects:	Innate Immunity and Inflammation
Online Access:	https://ncbi.nlm.nih.gov/pmc/articles/PMC4472943/ https://ncbi.nlm.nih.gov/pubmed/26019272 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.1402830
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Dual-Specificity Phosphatase 1 and Tristetraprolin Cooperate To Regulate Macrophage Responses to Lipopolysaccharide

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