Dual-Specificity Phosphatase 1 and Tristetraprolin Cooperate To Regulate Macrophage Responses to Lipopolysaccharide

Dual-specificity phosphatase (DUSP) 1 dephosphorylates and inactivates members of the MAPK superfamily, in particular, JNKs, p38α, and p38β MAPKs. It functions as an essential negative regulator of innate immune responses, hence disruption of the Dusp1 gene renders mice extremely sensitive to a wide...

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Detalles Bibliográficos
Publicado en:J Immunol
Autores principales: Smallie, Tim, Ross, Ewan A., Ammit, Alaina J., Cunliffe, Helen E., Tang, Tina, Rosner, Dalya R., Ridley, Michael L., Buckley, Christopher D., Saklatvala, Jeremy, Dean, Jonathan L., Clark, Andrew R.
Formato: Artigo
Lenguaje:Inglês
Publicado: AAI 2015
Materias:
Innate Immunity and Inflammation
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC4472943/
https://ncbi.nlm.nih.gov/pubmed/26019272
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.1402830
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