Block of NMDA receptor channels by endogenous neurosteroids: implications for the agonist induced conformational states of the channel vestibule

N-methyl-D-aspartate receptors (NMDARs) mediate synaptic plasticity, and their dysfunction is implicated in multiple brain disorders. NMDARs can be allosterically modulated by numerous compounds, including endogenous neurosteroid pregnanolone sulfate. Here, we identify the molecular basis of the use...

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Publicat a:Sci Rep
Autors principals: Vyklicky, Vojtech, Krausova, Barbora, Cerny, Jiri, Balik, Ales, Zapotocky, Martin, Novotny, Marian, Lichnerova, Katarina, Smejkalova, Tereza, Kaniakova, Martina, Korinek, Miloslav, Petrovic, Milos, Kacer, Petr, Horak, Martin, Chodounska, Hana, Vyklicky, Ladislav
Format: Artigo
Idioma:Inglês
Publicat: Nature Publishing Group 2015
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4471902/
https://ncbi.nlm.nih.gov/pubmed/26086919
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep10935
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