Block of NMDA receptor channels by endogenous neurosteroids: implications for the agonist induced conformational states of the channel vestibule

N-methyl-D-aspartate receptors (NMDARs) mediate synaptic plasticity, and their dysfunction is implicated in multiple brain disorders. NMDARs can be allosterically modulated by numerous compounds, including endogenous neurosteroid pregnanolone sulfate. Here, we identify the molecular basis of the use...

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Bibliografske podrobnosti
izdano v:Sci Rep
Main Authors: Vyklicky, Vojtech, Krausova, Barbora, Cerny, Jiri, Balik, Ales, Zapotocky, Martin, Novotny, Marian, Lichnerova, Katarina, Smejkalova, Tereza, Kaniakova, Martina, Korinek, Miloslav, Petrovic, Milos, Kacer, Petr, Horak, Martin, Chodounska, Hana, Vyklicky, Ladislav
Format: Artigo
Jezik:Inglês
Izdano: Nature Publishing Group 2015
Teme:
Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC4471902/
https://ncbi.nlm.nih.gov/pubmed/26086919
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep10935
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