Block of NMDA receptor channels by endogenous neurosteroids: implications for the agonist induced conformational states of the channel vestibule

N-methyl-D-aspartate receptors (NMDARs) mediate synaptic plasticity, and their dysfunction is implicated in multiple brain disorders. NMDARs can be allosterically modulated by numerous compounds, including endogenous neurosteroid pregnanolone sulfate. Here, we identify the molecular basis of the use...

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Veröffentlicht in:Sci Rep
Hauptverfasser: Vyklicky, Vojtech, Krausova, Barbora, Cerny, Jiri, Balik, Ales, Zapotocky, Martin, Novotny, Marian, Lichnerova, Katarina, Smejkalova, Tereza, Kaniakova, Martina, Korinek, Miloslav, Petrovic, Milos, Kacer, Petr, Horak, Martin, Chodounska, Hana, Vyklicky, Ladislav
Format: Artigo
Sprache:Inglês
Veröffentlicht: Nature Publishing Group 2015
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4471902/
https://ncbi.nlm.nih.gov/pubmed/26086919
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep10935
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